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R&D

Microbial Enzymes

What is α-Neoagaro-hydrolase?

Information

  • Parent Strain : Streptomyces coelicolor A3(2)
  • GH family : GH 117
  • Molecular weight : 41 kDa
  • Type : exo-type, break down the α-galactosidic bond
Feature

1. Hydrolyze neoagarobiose to anhydrogalactose and D-galactose
2. Hydrolyze neoagarotetraose to anhydrogalactose and agarotriose
3. Hydrolyze neoagarohexaose to anhydrogalactose and agaropentaose



R&D Directions

R&D process
Identification
Development of
Industrial strain
Scale up
Manufacturing
process
Quality Control
Validation of quality

Main products: Anhydrogalactose, Agarotriose, Agaropentaose

  • A galactan group
  • Inhibitory effect on tooth decay that replaced xylitol
  • Improving Irritable Bowel Syndrome through anti-inflammatory reactions
  • Structures

    성분명 3,6-Anhydro-D-galactose
    (CAS No. 14122-18-0)
    3,6-Anhydro-D-galactose 구조
    화학식 C₆H₁₀O₅
    분자량 162.14
    성분명 D-agarotriose
    (CAS No. 155015-96-6)
    D-agarotriose 구조
    화학식 C₁₈H₃₀O₁₅
    분자량 486.4
    성분명 D-agaropentaose
    (CAS No. 155015-99-9)
    D-agaropentaose 구조
    화학식 C₃₀H₄₈O₂₄
    분자량 792.7



Reference

Maral Tsevelkhoroloo et al. (2023) Appl Microbiol Biotech. 107:3997-4008 (doi: 10.1007/s00253-023-12552-x)